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Figure 17.12 Interhospital connection between a clinical PACS and an off-line archive server with an ASL model. Compare with Figure 17.11. Blue box: data embedding performed; orange box: assurance of image authenticity and integrity performed; various green boxes: PACS security server.

P1: FCH WY050-10 WY050-Ulick-v4 September 19, 2004 12:4

The guideline also states that where the manufacturer of a nonsterile API either intends or claims that it is suitable for use for further processing to produce a sterile drug product, water used in the nal isolation and puri cation steps for such API should be monitored and controlled for total microbial counts, objectionable microorganisms, and endotoxins (Q7A Section 43) The guideline recommends cleaning of equipment assigned for continuous production or campaign production of successive batches of the same intermediate or API at appropriate intervals to prevent buildup and carryover of objectionable levels of microorganisms (Q7A Sections 52 and 85) Under the laboratory controls section of the guideline, ICH recommends that if the API has a speci cation for microbiological purity, appropriate action limits for total microbial counts, objectionable organisms, and endotoxins should be established and met (Q7A Section 111).

nucleotide. Near the top of the autoradiogram it will be dif cult to resolve slight differences in electrophoretic mobility between different DNA fragments and this represents the limit of reliable sequencing in this experiment. From the rules of complementary base pairing, it is elementary to deduce the sequence of the parent strand from that of the complementary strand and, in the case of coding DNA, to translate this into a deduced amino acid sequence. Since even a single error in sequence may result in large errors

Appropriate microbiological speci cation tests should be conducted on each batch of intermediate or API where microbial quality is speci ed (Q7A Section 112) The guidelines specify that equipment cleaning/sanitation studies should address microbiological and endotoxin contamination for those processes where there is a need to reduce total microbiological count or endotoxins in the API, where a nonsterile API is used to manufacture sterile products (Q7A Section 127) For APIs manufactured by cell culture, fermentation techniques, raw materials used such as media, and buffer components may have potential for microbiological contamination For example, in such cases, depending on the intended use of the API or intermediate, control of bioburden, viral contamination, and/or endotoxins during manufacturing and monitoring of the process at appropriate stages may be necessary (Q7A Section 181).

These are all hallmarks of a Web 2.0 Ajax-based application. The hype surrounding Web 2.0 suggests that the World Wide Wait is over. Indeed, your first exposure to an Ajax application provides a neverbefore-experienced level of interactivity enabled by a different way of thinking about web-based application design.

Reading this list, we can only conclude that not much changed in the 27 years that have passed since Godin s survey. In the next section (7.2), we will attest this statement by exploring the gap between theory and practice of interactive scheduling systems. This problem exploration will focus respectively on the lack of empirical research in planning and scheduling, the lack of a comprehensive framework for design of scheduling support, and the domain-oriented approach that is often taken in designing scheduling algorithms. In Sections 7.3 and 7.4 we propose how the development of interactive scheduling systems can be improved. In Section 7.3 we use hierarchies in planning to link domain models to models of the task division and task execution. Furthermore, we propose a framework for scheduling system development in which the domain and task models are linked to a reusable library of scheduling speci c components. In Section 7.4 we extend the use of hierarchical models to the design of algorithms. By providing a structure with which algorithms can be designed for subtasks rather than for scheduling problems, we expect the chances that algorithms will actually be used in practice to rise.

When the quality of the API can be affected by microbial contamination, manipulations using open vessels should be performed in a biosafety cabinet or similarly controlled environment (Q7A Section 183) 6323 GMPs for Bulk Pharmaceutical Excipients.

An equivalent circuit of the model as in eqs. (3.53) (3.56)

Loss of excess weight (%) (b)

Frequency (MHz)

268 270